Generate — Regenerative Treatment
Clinically validated cellular regeneration using the Plinest range. Stimulates collagen and elastin from within for progressive, natural improvement in skin quality.
Price
From £350
Eyes, single session
Time
30 min
Per session
Discomfort
2 / 5
Numbing available
Downtime
Minimal
1–2 days mild
Sessions
2–3 initially
Then yearly
Polynucleotides (PDRN) are naturally occurring molecules derived from highly purified salmon DNA. At REGEN Clinic we use the Plinest range — one of the most clinically validated polynucleotide products available. Injected into the skin, they stimulate cellular repair, increase collagen production, and improve overall skin quality over a course of treatments.
Polynucleotides work differently to fillers or biorevitalisers. They do not add volume or hydration directly — they signal the skin's own repair mechanisms to regenerate from within. The result is a progressive, natural improvement in skin density, firmness, and radiance.
Polynucleotides are particularly effective for the under-eye area — where the skin is thin and conventional treatments carry higher risk — and the full face. They are also used for texture issues, crepey skin, and post-acne scarring.
Results build progressively over 4–8 weeks following each treatment. The initial course of 2–3 sessions, spaced 3–4 weeks apart, produces the most noticeable cumulative improvement. Many clients continue with yearly maintenance once they have achieved their desired result.
The REGEN Method
Polynucleotides are a core Generate treatment — working at a cellular level to restore the skin's regenerative capacity. They are frequently paired with a Profhilo or PRP sequence, and always follow an Elevate homecare plan to maximise the cellular environment for repair.
Discover The REGEN MethodReveal
Doctor-led skin assessment and goal-setting
Elevate
Personalised medical-grade homecare plan
Generate
Regenerative treatments — Profhilo, PRP, polynucleotides
Nurture
Ongoing reviews, adjusted plans, long-term partnership
Common Questions
Your practitioner
All injectable treatment at REGEN Clinic is performed personally by Dr Christopher Lalemi (GMC 7560090), who trained at King's College London and spent five years in NHS plastic and reconstructive surgery before founding REGEN. Every treatment is preceded by a face-to-face medical assessment. More about Dr Chris →
Polynucleotides stimulate the skin's own repair and regeneration mechanisms. They do not add volume. Instead they signal fibroblasts to produce more collagen and elastin, improving skin density, elasticity, and tone progressively over several weeks.
Most clients begin with a course of 2–3 sessions spaced 3–4 weeks apart. The under-eye course is typically 2 sessions; the face course is typically 3. Results continue to improve for 4–8 weeks after each treatment.
Yes. The Plinest range used at REGEN is highly purified and extensively clinically validated. Polynucleotides are biocompatible and biodegradable. Mild redness and swelling at injection sites typically resolve within 24–48 hours.
Fillers add volume or structure. Polynucleotides improve skin quality. They are often used together — polynucleotides to improve the skin's baseline condition, fillers or other injectables to address structural concerns. Dr Chris will advise on the right combination for you.
Yes — and this is one of the strongest applications. The under-eye area has very thin skin that responds well to the regenerative signal of polynucleotides. Results in this area are often particularly noticeable, with reduced hollowness, improved texture, and reduction in dark circles caused by skin thinning.
Still deciding?
If you’re weighing up your options, our short Treatment Finder takes your concerns, your goals and your timing — and points you to the treatment, plan or consultation that suits, in about three minutes. If you already know, you can book above.
Considering your options
A Reveal Consultation is designed for exactly this: a structured, doctor-led assessment of your skin, your goals and your medical history. Dr Chris will advise honestly whether Polynucleotides are the right starting point — or whether a different approach would serve you better.
Book a Consultation£75 — redeemable against same-day treatmentFurther reading from Dr Chris
Part of the REGEN Skin Boosters & Bio-Stimulators range.
Client Reviews
Genuine five-star reviews from verified Fresha bookings — read all 431+ on Fresha.
Exceptional experience. Dr Lalemi was prompt, precise and made the session beautifully efficient. Despite my fear of injections, the treatment was completely comfortable thanks to his thoughtful approach. I had Polynucleotides and my skin already feels firmer and more lifted around the neck and temples. Discreet, expert and highly recommended.
Have seen Dr Chris a few times now and he always provides an excellent, professional service! He has really helped me with my skin concerns and my skin has really improved since starting his recommend treatments
Great! I was quite anxious but Dr Chris was very professional, reassuring and put me at ease. Which made for a great experience, I will return with no worries and will also recommend to others without hesitation. Highly recommend.
Really enjoyed my treatment with Cam today. So relaxing and professional. Could have laid there all day! Would definitely recommend. Thank you
